CHANGES IN VERSION 1.58.0
-------------------------

NEW FEATURES

    o The TxDb class now extends the new OutOfMemoryObject class defined in
      BiocGenerics (virtual class with no slots).

    o Calling saveRDS() on a TxDb object now raises an error with a message
      that redirects the user to AnnotationDbi::saveDb().


CHANGES IN VERSION 1.56.0
-------------------------

NEW FEATURES

    o Add getTerminatorSeq(). Same as getPromoterSeq() but for terminator
      sequences.

SIGNIFICANT USER-VISIBLE CHANGES

    o The makeTxDb*() functions and related have moved to the new txdbmaker
      package. Full list:
        - makeTxDb
        - supportedUCSCtables
        - browseUCSCtrack
        - makeTxDbFromUCSC
        - getChromInfoFromBiomart
        - makeTxDbFromBiomart
        - makeTxDbFromEnsembl
        - makeTxDbFromGRanges
        - makeTxDbFromGFF
        - supportedUCSCFeatureDbTracks
        - supportedUCSCFeatureDbTables
        - UCSCFeatureDbTableSchema
        - makeFeatureDbFromUCSC
        - supportedMiRBaseBuildValues
        - makePackageName
        - makeTxDbPackage
        - makeTxDbPackageFromUCSC
        - makeFDbPackageFromUCSC
        - makeTxDbPackageFromBiomart
      Note that they are still temporarily defined in GenomicFeatures but now
      they just call the corresponding function in txdbmaker. Since this is a
      temporary redirect, the user also gets a warning that tells them to use
      the fully qualified name (e.g. txdbmaker::makeTxDbFromUCSC()) to call
      the function.


CHANGES IN VERSION 1.54.0
-------------------------

SIGNIFICANT USER-VISIBLE CHANGES

    o Fix flaw in heuristic for inferring exon ranks in makeTxDbFromGRanges():
      makeTxDbFromGRanges() can guess the exon ranks of a given transcript
      either
        (a) based on their position on the chromosome
        (b) or by looking at the suffixes of the exon ids (e.g. .1, .2, etc...)
            if any
      Previously (i.e. in GenomicFeatures < 1.53.1) it was trying (b) first,
      and would fall back on (a) if (b) failed.
      Starting with GenomicFeatures 1.53.1, it does the opposite: it tries (a)
      first, and uses (b) only for exons for which (a) failed.
      This change addresses the problem that the suffixes of the exon ids cannot
      be trusted to infer the ranks of exons located on the minus strand. See
      https://github.com/Bioconductor/GenomicFeatures/issues/59 for an example.

    o Try to more clearly distinguish between CDS and CDS parts in
      documentation.

BUG FIXES

    o Switch from HTTP to HTTPS for requests to *.ucsc.edu


CHANGES IN VERSION 1.52.0
-------------------------

NEW FEATURES

    o Small improvement to makeTxDbFromEnsembl(): The function can now be
      called on the abbreviated organism, e.g. "hsapiens", in addition
      to "homo sapiens".

DEPRECATED AND DEFUNCT

    o Finally remove disjointExons() (got deprecated in BioC 3.13 and defunct
      in BioC 3.15).

BUG FIXES

    o Fix issue with order of sequences in seqinfo(makeTxDbFromUCSC()).
      See commit e4381bc.


CHANGES IN VERSION 1.50.0
-------------------------

SIGNIFICANT USER-VISIBLE CHANGES

    o Use useEnsemblGenomes() instead of useMart() wherever possible.

    o Improve pcoverageByTranscript() implementation. The function now uses
      a chunking strategy to handle bigger CompressedGRangesList objects and
      to reduce memory footprint. Note that even with this improvement, the
      function is still not very efficient.

    o Rename proteinToGenome() argument 'txdb' -> 'db'.

BUG FIXES

    o Change test for 'circ_seqs' argument in makeTxDbPackageFromUCSC() from
      an error to a warning if argument set to NULL.


CHANGES IN VERSION 1.48.0
-------------------------

NEW FEATURES

    o Add proteinToGenome() generic and methods. Loosely modeled on
      ensembldb::proteinToGenome().

    o Add extendExonsIntoIntrons().

SIGNIFICANT USER-VISIBLE CHANGES

    o Use useEnsembl() instead of useMart() wherever possible.

    o makeTxDbFromGFF() and makeTxDbFromGRanges() now recognize and
      import features of type "gene_segment", "pseudogenic_gene_segment",
      "antisense_RNA", "three_prime_overlapping_ncrna", or "vault_RNA",
      as transcripts.
      Note that, according to the Sequence Ontology, the "gene_segment"
      and "pseudogenic_gene_segment" terms are NOT offsprings of the
      "transcript" term via the **is_a** relationship but we still treat
      them as if they were because that's what Ensembl does in their GFF3
      files!

DEPRECATED AND DEFUNCT

    o Add warning about FeatureDb-related functionalities no longer being
      actively maintained.

    o disjointExons() is now defunct after being deprecated in BioC 3.13.


CHANGES IN VERSION 1.46.0
-------------------------

SIGNIFICANT USER-VISIBLE CHANGES

    o Small update to makeTxDbFromGFF()/makeTxDbFromGRanges():
      makeTxDbFromGFF() and makeTxDbFromGRanges() now recognize and import
      features of type protein_coding_gene (or of type any offspring of
      the protein_coding_gene term) as genes. This was achieved by adding
      protein_coding_gene + its offsprings to GenomicFeatures:::.GENE_TYPES.


CHANGES IN VERSION 1.44.0
-------------------------

SIGNIFICANT USER-VISIBLE CHANGES

    o Several improvements to makeTxDbFromGFF():
      - More GFF3 feature types are recognized as transcripts or genes (commit
        d7f5980f).
      - Improve handling of GFF3 files from Ensembl (commit c1e3fb92).
      - Handle exons with no Parent attribute. GFF3 files that contain exons
        with no Parent attribute no longer break makeTxDbFromGRanges() or
        makeTxDbFromGFF(). Orphan exons are dropped.

DEPRECATED AND DEFUNCT

    o Deprecate disjointExons() in favor of exonicParts().

    o Remove species() method for TxDb objects (was deprecated in BioC 3.3
      and defunct in BioC 3.4).


CHANGES IN VERSION 1.42.0
-------------------------

NEW FEATURES

    o Implement a restricted seqinfo() setter for TxDb objects that supports
      altering only the seqlevels and/or genome of the object, but not its
      seqlengths or circularity flags. This is all we need to make the improved
      seqlevelsStyle() setter work on TxDb objects (see below).

SIGNIFICANT USER-VISIBLE CHANGES

    o The seqlevelsStyle() getter and setter do a better job when the
      underlying genome is known. See NEWS file in the GenomeInfoDb package
      for more information.


CHANGES IN VERSION 1.40.0
-------------------------

NEW FEATURES

    o Small improvements to makeTxDbFromEnsembl():
      - check validity of user supplied transcript attribute code
      - report nb of fetched transcripts and genes during progress
      - produced TxDb will "remember" which transcript attribute code was used

SIGNIFICANT USER-VISIBLE CHANGES

    o genes() now prints a message when genes are dropped.

    o getChromInfoFromUCSC() is now defined in the GenomeInfoDb package.
      Note that the new function is a much improved version of the old one
      but also the returned data frame has its columns named differently!
      See ?getChromInfoFromUCSC in the GenomeInfoDb package for the details.

    o Argument 'goldenPath_url' was renamed 'goldenPath.url' in functions
      makeTxDbFromUCSC(), makeFeatureDbFromUCSC(), makeTxDbPackageFromUCSC(),
      and makeFDbPackageFromUCSC().

    o Default value for argument 'circ_seqs' was changed from DEFAULT_CIRC_SEQS
      to NULL in all functions that have this argument.

    o Global constant DEFAULT_CIRC_SEQS (character vector) was removed. It is
      now defined in GenomeInfoDb but no longer exported, at least for now.

BUG FIXES

    o Make asGFF() method for TxDb objects robust to absence of CDS ranges.


CHANGES IN VERSION 1.38.0
-------------------------

NEW FEATURES

    o Small improvement to exonicParts() and intronicParts():
      - When 'linked.to.single.gene.only' is set to TRUE, exonicParts() now
        returns an additional "exonic_part" metadata column that indicates the
        rank of each exonic part within all the exonic parts linked to the same
        gene. This is for compatibility with old disjointExons().
      - intronicParts() does something similar except that the additional
        metadata column is named "intronic_part".

SIGNIFICANT USER-VISIBLE CHANGES

    o makeTxDbFromGRanges() and makeTxDbFromGFF() now recognize more features
      as transcripts, exons, or CDS (see commits 822665f8 and 6281f856)

BUG FIXES

    o Fix makeTxDbFromUCSC(..., "refGene") for bosTau9/galGal6/panTro6/rheMac10


CHANGES IN VERSION 1.36.0
-------------------------

NEW FEATURES

    o Export and document helper functions tidyTranscripts(), tidyExons(),
      and tidyIntrons()

    o Add support for mapToTranscripts() to map ranges that span introns

BUG FIXES

    o Fix bug in makeTxDbFromGFF() when file is a GFF3File or GTFFile object

    o Fix bug in makeFeatureDbFromUCSC()
      (see https://github.com/Bioconductor/GenomicFeatures/issues/15)

    o Fix makeTxDbFromUCSC() on hg19/refGene and hg38/refGene tables
      (see message of commit ee575ee8 for more information)


CHANGES IN VERSION 1.34.0
-------------------------

NEW FEATURES

    o 2 changes to makeTxDbFromGFF() / makeTxDbFromGRanges():
      - Now they support GFF3 files where the CDS parent is an exon instead
        of a transcript. Note that such GFF3 files are rare and not following
        the well established convention documented in the GFF3 specs:
        https://github.com/The-Sequence-Ontology/Specifications/blob/master/gff3.md
      - Now they accept missing/invalid CDS phases (with a warning).

    o makeTxDb() now accepts missing CDS phases.


CHANGES IN VERSION 1.32.0
-------------------------

NEW FEATURES

    o The first argument of mapToTranscripts() and pmapToTranscripts() now can
      be a GPos object and a GPos object is returned in that case.

    o Add 'use.names' argument to "transcripts", "exons", "cds, and "promoters"
      methods for TxDb objects.

    o makeTxDbFromUCSC() now uses direct SQL queries (to the UCSC MySQL server
      at genome-mysql.soe.ucsc.edu) instead of rtracklayer::getTable() to fetch
      data from the Genome Browser. This avoids the issue reported here
      https://github.com/lawremi/rtracklayer/issues/5 . Another benefit is
      that direct SQL queries are much faster than rtracklayer::getTable().

SIGNIFICANT USER-VISIBLE CHANGES

    o The GRanges object returned by mapToTranscripts() or pmapToTranscripts()
      takes the transcript lengths as seqlengths.

    o pmapToTranscripts() always takes the transcript name as the seqname,
      even when there is no overlap. Before, it used "UNMAPPED" as the seqname
      when there was no overlap.

BUG FIXES

    o Fix bug where 'coverageByTranscript(x, transcripts)' was erroring in
      situations where 'transcripts' contains transcripts with an exon that
      receives no coverage and is located on a sequence for which the seqlength
      is not available in 'seqinfo(x)' nor in 'seqinfo(transcripts)'.


CHANGES IN VERSION 1.30.0
-------------------------

NEW FEATURES

    o Add makeTxDbFromEnsembl() for creating a TxDb object by querying
      directly an Ensembl MySQL server. This seems to be faster and more
      reliable than makeTxDbFromBiomart().

    o Improve makeTxDbFromBiomart() support for EnsemblGenomes marts
      fungal_mart, metazoa_mart, plants_mart, and protist_mart.

    o makeTxDbFromGFF() and makeTxDbFromGRanges() now import the CDS phase.
      This required a change in the schema of the underlying SQLite db of
      TxDb objects. This is still a work-in-progress e.g. cdsBy(txdb, by="tx")
      still needs to be modified to return the phase info.

SIGNIFICANT USER-VISIBLE CHANGES

    o The *ByOverlaps() functions now use the same 'maxgap' and 'minoverlap'
      defaults as subsetByOverlaps().

DEPRECATED AND DEFUNCT

    o Remove 'force' argument from seqinfo() and seqlevels() setters (the
      argument got deprecated in BioC 3.5 in favor of new and more flexible
      'pruning.mode' argument).

BUG FIXES

    o exonicParts() and intronicParts() are now documented.

    o Address a couple of issues pointed out by Matt Chambers in
      internal helpers get_organism_from_Ensembl_Mart_dataset() and
      .extractEnsemblReleaseFromDbVersion() used by makeTxDbFromBiomart().

    o Fix internal utility .Ensembl_getMySQLCoreDir(). Was failing for some
      of the 69 datasets from the Ensembl mart, causing makeTxDbFromBiomart()
      to fail loopking up the organism scientific name and the chromosome
      lengths. Thanks to Matt Chambers for reporting this.

    o Some tweaks and fixes needed to support RSQLite 2.0.


CHANGES IN VERSION 1.28.0
-------------------------

NEW FEATURES

    o makeTxDbFromUCSC() supports new composite "NCBI RefSeq" track for hg38.

    o Add 'metadata' argument to makeTxDbFromGFF().

    o Add exonicParts() as an alternative to disjointExons():
      - exonicParts() has a 'linked.to.single.gene.only' argument (FALSE by
        default) that is similar to the 'aggregateGenes' argument of
        disjointExons() but with opposite meaning. More precisely
        'exonicParts(txdb, linked.to.single.gene.only=TRUE)' returns the same
        exonic parts as 'disjointExons(txdb, aggregateGenes=FALSE)'.
      - Unlike 'disjointExons(txdb, aggregateGenes=TRUE)',
        'exonicParts(txdb, linked.to.single.gene.only=FALSE)' does NOT discard
        exon parts that are not linked to a gene.
      - exonicParts() is almost twice more efficient than disjointExons().

    o Add intronicParts(): similar to exonicParts() but returns intronic parts.

SIGNIFICANT USER-VISIBLE CHANGES

    o Some work on distance,GenomicRanges,TxDb method:
      - pass ignore.strand to range() and distance()
      - return NA when 'id' cannot be collapsed into a single range or when
        'id' is not found in 'y'

DEPRECATED AND DEFUNCT

    o Argument 'force' of seqlevels() setters is deprecated in favor of new and
      more flexible 'pruning.mode' argument.

    o Remove the 'vals' argument of the "transcripts", "exons", "cds", and
      "genes" methods for TxDb objects (was defunct in BioC 3.4).

BUG FIXES

    o Fix bug in seqlevels() setter for TxDb objects reported here:
        https://support.bioconductor.org/p/90226/


CHANGES IN VERSION 1.26.0
-------------------------

NEW FEATURES

    o makeTxDbFromGRanges() now recognizes features of type lnc_RNA,
     antisense_lncRNA, transcript_region, and pseudogenic_tRNA, as transcripts.

    o Add 'intronJunctions' argument to mapToTranscripts().

DEPRECATED AND DEFUNCT

    o The 'vals' argument of the "transcripts", "exons", "cds", and "genes"
      methods for TxDb objects is now defunct (was deprecated in BioC 3.3).

    o The "species" method for TxDb object is now defunct (was deprecated in
      BioC 3.3).


CHANGES IN VERSION 1.24.0
-------------------------

NEW FEATURES

    o Add mapRangesToIds() and mapIdsToRanges() for mapping genomic ranges to
      IDs and vice-versa.

    o Support makeTxDbFromUCSC("hg38", "knownGene") (gets "GENCODE v22" track).

    o Add pmapToTranscripts,GRangesList,GRangesList method.

SIGNIFICANT USER-VISIBLE CHANGES

    o Rename the 'vals' argument of the transcripts(), exons(), cds(), and
      genes() extractors -> 'filter'. The 'vals' argument is still available
      but deprecated.

    o Rename the 'filters' argument of makeTxDbFromBiomart() and
      makeTxDbPackage() -> 'filter'.

    o When grouping the transcripts by exon or CDS, transcriptsBy() now returns
      a GRangesList object with the "exon_rank" information (as an inner
      metadata column).

    o For transcripts with no exons (like in the GFF3 files from GeneDB),
      makeTxDbFromGRanges() now infers the exons from the CDS.

    o For transcripts with no exons and no CDS (like in the GFF3 files from
      miRBase), makeTxDbFromGRanges() now infers the exon from the transcript.

    o makeTxDbFromGRanges() and makeTxDbFromGFF() now support GFF/GTF files
      with one (or both) of the following peculiarities:
      - The file is GTF and contains only lines of type transcript but no
        transcript_id tag (not clear this is valid GTF but some users are
        working with this kind of file).
      - Each transcript in the file is reported to be on its own contig and
        spans it (start=1) but no strand is reported for the transcript.
        makeTxDbFromGRanges() now sets the strand to "+" for all these
        transcripts.

    o makeTxDbFromGRanges() now recognizes features of type miRNA,
      miRNA_primary_transcript, SRP_RNA, RNase_P_RNA, RNase_MRP_RNA, misc_RNA,
      antisense_RNA, and antisense as transcripts. It also now recognizes
      features of type transposable_element_gene as genes.

    o makeTxDbFromBiomart() now points to the Ensembl mart by default instead
      of the central mart service.

    o Add some commonly used alternative names (Mito, mitochondrion,
      dmel_mitochondrion_genome, Pltd, ChrC, Pt, chloroplast, Chloro, 2uM) for
      the mitochondrial and chloroplast genomes to DEFAULT_CIRC_SEQS.

DEPRECATED AND DEFUNCT

    o Remove the makeTranscriptDb*() functions (were defunct in BioC 3.2).

    o Remove the 'exonRankAttributeName', 'gffGeneIdAttributeName',
      'useGenesAsTranscripts', 'gffTxName', and 'species' arguments from the
      makeTxDbFromGFF() function (were defunct in BioC 3.2).

BUG FIXES

    o Try to improve heuristic used in makeTxDbFromGRanges() for detecting the
      format (GFF3 or GTF) of input GRanges object 'x'.


CHANGES IN VERSION 1.22.0
-------------------------

NEW FEATURES

    o Add coverageByTranscript() and pcoverageByTranscript(). See
      ?coverageByTranscript for more information.

    o Various improvements to makeTxDbFromGFF():
      - Now supports 'format="auto"' for auto-detection of the file format.
      - Now supports naming features by dbxref tag (like GeneID). This has
        proven useful when importing GFFs from NCBI.

    o Improvements to the coordinate mapping methods:
      - Support recycling when length(transcripts) == 1 for parallel
        mapping functions.
      - Add pmapToTranscripts,Ranges,GRangesList and
        pmapFromTranscripts,Ranges,GRangesList methods.

    o Adds 'taxonomyId' argument to the makeTxDbFrom*() functions.

    o Improvements to makeTxDbPackage():
      - Add 'pkgname' argument to makeTxDbPackage() to let the user override
        the automatic naming of the package to be generated.
      - Support person objects for 'maintainer' and 'author' arguments to
        makeTxDbPackage().

    o The 'chrominfo' vector passed to makeTxDb() can now mix NAs and non-NAs.

SIGNIFICANT USER-VISIBLE CHANGES

    o 2 significant changes to makeTxDbFromGRanges() and makeTxDbFromGFF():
      - They now also import transcripts of type pseudogenic_transcript and
        pseudogenic_exon.
      - They normally get the "gene_id" and "[tx|exon|CDS]_name" columns from
        the Name tag. Now they will also infer these columns from the ID tag
        when the Name tag is missing.

    o Improve handling of 'circ_seqs' argument by makeTxDbFromUCSC(),
      makeTxDbFromGFF(), and makeTxDbFromBiomart(): no more annoying warning
      when none of the strings in DEFAULT_CIRC_SEQS matches the seqlevels of
      the TxDb object to be made.

    o 2 minor changes to makeTxDbFromBiomart():
      - Now drops unneeded chromosome info when importing an incomplete
        transcript dataset.
      - Now returns a TxDb object with 'Full dataset' field set to 'no' when
        makeTxDbFromBiomart() is called with user-supplied 'filters'.

    o makeTxDbPackage() now includes data source in the package name by default
      (for non UCSC and BioMart databases).

    o The following changes were made to the coordinate mapping methods:
      - mapToTranscripts() now reports mapped position with respect to the
        transcription start site regardless of strand.
      - Change 'ignore.strand' default from TRUE to FALSE in all coordinate
        mapping methods for consistency with other functions that already have
        the 'ignore.strand' argument.
      - Name matching in mapFromTranscripts() is now done with seqnames(x) and
        names(transcripts).
      - The pmapFromTranscripts,*,GRangesList methods now return a GRangesList
        object. Also they no longer use 'UNMAPPED' seqname for unmapped ranges.
      - Remove uneeded ellipisis from the argument list of various coordinate
        mapping methods.

    o Change behavior of seqlevels0() getter so it does what it was always
      intended to do.

    o The order of the transcripts returned by transcripts() has changed: now
      they are guaranteed to be in the same order as in the GRangesList object
      returned by exonsBy().

    o Code improvements and speedup to the transcripts(), exons(), cds(),
      exonsBy(), and cdsBy() extractors.

    o In order to avoid loss of information (and make it reversible with
      makeTxDbFromGRanges()), the "asGFF" method for TxDb objects now
      propagates the "exon_name" and "cds_name" columns to the GRanges object.

DEPRECATED AND DEFUNCT

    o After being deprecated in BioC 3.1, the makeTranscriptDb*() functions
      are now defunct.

    o After being deprecated in BioC 3.1, the 'exonRankAttributeName',
      'gffGeneIdAttributeName', 'useGenesAsTranscripts', 'gffTxName', and
      'species' arguments of makeTxDbFromGFF() are now defunct.

    o Remove sortExonsByRank() (was defunct in BioC 3.1).

BUG FIXES

    o Fix bug in fiveUTRsByTranscript() and threeUTRsByTranscript() extractors
      when the TxDb object had "user defined" seqlevels and/or a set of
      "active/inactive" seqlevels defined on it.

    o Fix bug in isActiveSeq() setter when the TxDb object had "user defined"
      seqlevels on it.

    o Fix many issues with seqlevels() setter for TxDb objects. In particular
      make the 'seqlevels(x) <- seqlevels0(x)' idiom work on TxDb objects.

    o Fix bug in makeTxDbFromBiomart() when using it to retrieve a dataset that
      doesn't provide the cds_length attribute (e.g. sitalica_eg_gene dataset
      in plants_mart_26).


CHANGES IN VERSION 1.20.0
-------------------------

NEW FEATURES

    o Add makeTxDbFromGRanges() for extracting gene, transcript, exon, and CDS
      information from a GRanges object structured as GFF3 or GTF, and
      returning that information as a TxDb object.

    o TxDb objects have a new column ("tx_type" in the "transcripts" table)
      that the user can request thru the 'columns' arg of the transcripts()
      extractor. This column is populated when the user makes a TxDb object
      from Ensembl (using makeTxDbFromBiomart()) or from a GFF3/GTF file (using
      makeTxDbFromGFF()), but not yet (i.e. it's set to NA) when s/he makes it
      from a UCSC track (using makeTxDbFromUCSC()). However it seems that UCSC
      is also providing that information for some tracks so we're planning to
      have makeTxDbFromUCSC() get it from these tracks in the near future.
      Also low-level makeTxDb() now imports the "tx_type" column if supplied.

    o Add transcriptLengths() for extracting the transcript lengths from a
      TxDb object. It also returns the CDS and UTR lengths for each transcript
      if the user requests them.

    o extractTranscriptSeqs() now works on a FaFile or GmapGenome object (or,
      more generally, on any object that supports seqinfo() and getSeq()).

SIGNIFICANT USER-VISIBLE CHANGES

    o Renamed makeTranscriptDbFromUCSC(), makeTranscriptDbFromBiomart(),
      makeTranscriptDbFromGFF(), and makeTranscriptDb() -> makeTxDbFromUCSC(),
      makeTxDbFromBiomart(), makeTxDbFromGFF(), and makeTxDb(). Old names
      still work but are deprecated.

    o Many changes and improvements to makeTxDbFromGFF():
      - Re-implemented it on top of makeTxDbFromGRanges().
      - The geneID tag, if present, is now used to assign an external gene id
        to transcripts that couldn't otherwise be linked to a gene. This is
        for compatibility with some GFF3 files from FlyBase (see for example
        dmel-1000-r5.11.filtered.gff included in this package).
      - Arguments 'exonRankAttributeName', 'gffGeneIdAttributeName',
        'useGenesAsTranscripts', and 'gffTxName', are not needed anymore so
        they are now ignored and deprecated.
      - Deprecated 'species' arg in favor of new 'organism' arg.

    o Some tweaks to makeTxDbFromBiomart():
      - Drop transcripts with UTR anomalies with a warning instead of failing.
        We've started to see these hopeless transcripts with the release 79 of
        Ensembl in the dmelanogaster_gene_ensembl dataset (based on FlyBase
        r6.02 / FB2014_05). With this change, the user can still make a TxDb
        for dmelanogaster_gene_ensembl but some transcripts will be dropped
        with a warning.
      - BioMart data anomaly warnings and errors now show the first 3
        problematic transcripts instead of 6.

    o 'gene_id' metadata column returned by genes() is now a character vector
      instead of a CharacterList object.

    o Use # prefix instead of | in "show" method for TxDb objects.

DEPRECATED AND DEFUNCT

    o Deprecated makeTranscriptDbFromUCSC(), makeTranscriptDbFromBiomart(),
      makeTranscriptDbFromGFF(), and makeTranscriptDb(), in favor of
      makeTxDbFromUCSC(), makeTxDbFromBiomart(), and makeTxDbFromGFF(), and
      makeTxDb().

    o Deprecated species() accessor in favor of organism() on TxDb objects.

    o sortExonsByRank() is now defunct (was deprecated in GenomicFeatures
      1.18)

    o Removed extractTranscriptsFromGenome(), extractTranscripts(),
      determineDefaultSeqnameStyle() (were defunct in GenomicFeatures 1.18).

BUG FIXES

    o makeTxDbFromBiomart():
      - Fix issue causing the download of 'chrominfo' data frame to fail when
        querying the primary Ensembl mart (with host="ensembl.org" and
        biomart="ENSEMBL_MART_ENSEMBL").
      - Fix issue with error reporting code: when some transcripts failed to
        pass the sanity checks, the error message was displaying the wrong
        transcripts. More precisely, many good transcripts were mistakenly
        added to the set of bad transcripts and included in the error message.

    o extractTranscriptSeqs(): fix error message when internal call to
      exonsBy() fails on 'transcripts'.


CHANGES IN VERSION 1.18.0
-------------------------

NEW FEATURES

    o Add extractUpstreamSeqs().

    o makeTranscriptDbFromUCSC() now supports the "flyBaseGene" table
      (FlyBase Genes track).

    o makeTranscriptDbFromBiomart() now knows how to fetch the sequence
      lengths from the Ensembl Plants db.

    o makeTranscriptDbFromGFF() is now more tolerant of bad strand
      information.

SIGNIFICANT USER-VISIBLE CHANGES

    o Replace toy TxDb UCSC_knownGene_sample.sqlite (based on hg18) with
      hg19_knownGene_sample.sqlite (based on hg19) and use hg19 instead of
      hg18 in all examples (and unit tests).

    o Rename TranscriptDb class -> TxDb.

    o Now when GTF files are processed into TxDbs with exon ranking being
      inferreed, if the exons are on separate chromosomes, we toss out that
      transcript (since we cannot possibly guess the exon ranking correctly).

DEPRECATED AND DEFUNCT

    o extractTranscripts() and extractTranscriptsFromGenome() are now defunct.

    o Deprecate sortExonsByRank().

BUG FIXES

    o Bug fixes and improvements to makeTranscriptDbFromBiomart():
      (a) Fix long standing bug where the code in charge of inferring the
          CDSs from the UTRs would return CDSs spanning all the exons of a
          non-coding transcript.
      (b) Fix an issue that was preventing the function from extracting the
          CDS information added recently to the datasets in the Ensembl Fungi,
          Ensembl Metazoa, Ensembl Plants, and Ensembl Protists databases.
      (c) Make the code in charge of extracting the CDSs more robust by taking
          advantage of new attributes (genomic_coding_start and
          genomic_coding_end) added by Ensembl in release 74 (Dec 2013),
          and by adding more sanity checks.


CHANGES IN VERSION 1.14.0
-------------------------

NEW FEATURES

    o keys method now has new arguments to allow for more
      sophisticated filtering.

    o adds genes() extractor

    o makeTranscriptDbFromGFF() now handles even more different kinds
      of GFF files.


BUG FIXES

    o better argument checking for makeTranscriptDbFromGFF()

    o cols arguments and methods will now be columns arguments and methods


CHANGES IN VERSION 1.12.0
-------------------------

NEW FEATURES

    o Support for new UCSC species

    o Better support for GTF and GFF processing into TranscriptDb objects

    o Methods for making TranscriptDb objects from general sources
      have been made more useful

BUG FIXES

    o Updates to allow continued access to ever changing services like UCSC

    o Corrections for seqnameStyle methods

    o Over 10X performance gains for processing of GTF and GFF files


CHANGES IN VERSION 1.10.0
-------------------------

NEW FEATURES

    o Add makeTranscriptDbFromGFF().  Users can now use GFF files to
      make TranscriptDb resources.

    o Add *restricted* "seqinfo<-" method for TranscriptDb objects. It only
      supports replacement of the sequence names (for now), i.e., except for
      their sequence names, Seqinfo objects 'value' (supplied) and 'seqinfo(x)'
      (current) must be identical.

    o Add promoters() and getPromoterSeq().

    o Add 'reassign.ids' arg (FALSE by default) to makeTranscriptDb().

SIGNIFICANT USER-VISIBLE CHANGES

    o Updated vignette.

    o Improve how makeTranscriptDbFromUCSC() and makeTranscriptDbFromBiomart()
      assign internal ids (see commit 65144 for the details).

    o 2.5x speedup of fiveUTRsByTranscript() and threeUTRsByTranscript().

DEPRECATED AND DEFUNCT

    o Are now defunct: transcripts_deprecated(), exons_deprecated(), and
      introns_deprecated().

    o Deprecate loadFeatures() and saveFeatures() in favor of loadDb() and
      saveDb(), respectively.

BUG FIXES

    o Better handling of BioMart data anomalies.


CHANGES IN VERSION 1.8.0
------------------------

NEW FEATURES

    o Added asBED and asGFF methods to convert a TranscriptDb to a
      GRanges that describes transcript structures according to either
      the BED or GFF format. This enables passing a TranscriptDb
      object to rtracklayer::export directly, when targeting GFF/BED.


CHANGES IN VERSION 1.6.0
------------------------

NEW FEATURES

    o TranscriptDbs are now available as standard packages.  Functions
    that were made available before the last release allow users to
    create these packages.

    o TranscriptDb objects now can be used with select

    o select method for TranscriptDb objects to extract data.frames of
    available annotations.  Users can specify keys, along with the
    keytype, and the columns of data that they want extracted from the
    annotation package.

    o keys now will operate on TranscriptDB objects to expose ID types
    as potential keys

    o keytypes will show which kinds of IDs can be used as a key by select

    o cols will display the kinds of data that can be extracted by select

    o isActiveSeq has been added to allow entire chromosomes to be
    toggled active/inactive by the user.  By default, everything is
    exposed, but if you wish you can now easily hide everything that
    you don't want to see.  Subsequence to this, all your accessors
    will behave as if only the "active" things are present in the
    database.

SIGNIFICANT USER-VISIBLE CHANGES

    o saveDb and loadDb are here and will be replacing saveFeatures
    and loadFeatures.  The reason for the name change is that they
    dispatch on (and should work with a wider range of object types
    than just trancriptDb objects (and their associated databases).

BUG FIXES

    o ORDER BY clause has been added to SQL statements to enforce more
    consistent ordering of returned rows.

    o bug fixes to enable DB construction to still work even after
    changes in schemas etc at UCSC, and ensembl sources.

    o bug fixes to makeFeatureDbFromUCSC allow it to work more
    reliably (it was being a little too optimistic about what UCSC
    would actually supply data for)

